Pd-catalyzed functionalization of alkenes and alkynes using removable tethers

The palladium-catalyzed functionalization of alkenes is a versatile transformation in synthetic chemistry, but intermolecular processes often suffer from low reactivity and selectivity. Molecular tethers can be introduced to answer these challenges. They have been used successfully for decades, their installation removal normally required multi-step procedures. In this review, we will present progress area resulting more efficient tethering processes. We start with brief overview carbamate- sulfone-based tethered allylic alcohol amine derivatives. Then the recent development that installed situ on (homo)-allyl/propargyl amines or alcohols double triple bond described. difunctionalization alkynes using trifluoro acetaldehyde based developed by our group covered details. Finally, introduce concept as catalytically formed chiral auxiliaries asymmetric synthesis.