PD29-09 TRIGLYCERIDE-GLUCOSE INDEX (TYG) IS ASSOCIATED WITH SPERM PARAMETERS AND SPERM DNA FRAGMENTATION IN PRIMARY INFERTILE MEN: A CROSS-SECTIONAL STUDY

You have accessJournal of UrologyInfertility: Epidemiology & Evaluation II (PD29)1 Sep 2021PD29-09 TRIGLYCERIDE-GLUCOSE INDEX (TYG) IS ASSOCIATED WITH SPERM PARAMETERS AND DNA FRAGMENTATION IN PRIMARY INFERTILE MEN: A CROSS-SECTIONAL STUDY Luca Boeri, Paolo Capogrosso, Edoardo Pozzi, Luigi Candela, Federico Belladelli, Walter Cazzaniga, Giuseppe Fallara, Nicolò Schifano, Eugenio Ventimiglia, Daniele Cignoli, Gianmarco Colandrea, Massimo Alfano, Costantino Abbate, Francesco Montorsi, and Andrea Salonia BoeriLuca Boeri More articles by this author , CapogrossoPaolo Capogrosso PozziEdoardo Pozzi CandelaLuigi Candela BelladelliFederico Belladelli CazzanigaWalter Cazzaniga FallaraGiuseppe Fallara SchifanoNicolò Schifano VentimigliaEugenio Ventimiglia CignoliDaniele Cignoli ColandreaGianmarco Colandrea AlfanoMassimo Alfano AbbateCostantino Abbate MontorsiFrancesco Montorsi SaloniaAndrea View All Author Informationhttps://doi.org/10.1097/JU.0000000000002030.09AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION OBJECTIVE: Male factor infertility (MFI) is often associated with metabolic disorders such as diabetes mellitus syndrome, where insulin resistance (IR) plays a relevant pathological role. The Homeostatic Model Assessment (HOMA) triglycerides/glucose index (TyG) are good marker IR. We aimed investigate the relationship between TyG both semen hormonal characteristics in cohort primary infertile men. METHODS: Complete demographic, clinical laboratory data from 726 consecutive men (infertility defined according WHO definition) were considered. Health-significant comorbidities scored Charlson Comorbidity Index (CCI). Serum hormone, analyses (based on 2010 reference criteria) sperm fragmentation (DFI) measured every patient. Glucose, triglycerides levels after 12-h overnight fast, HOMA-IR indices calculated classified using 2.6 threshold (as Ascaso et al. 2003) 8.1 Kang 2017), respectively. Descriptive statistics logistic regression models tested association milieu parameters. RESULTS: Median (IQR) age was 39 (35-43) years. HOMA suggestive for IR found 339 (46.6%) 154 (21.2%) patients, respectively 121 (16.7%) had both. At Spearman’s test, correlated score (rho = 0.46, p<0.001). Compared normal TyG, TyG>8.1 older [37 (34-41) vs. years], greater BMI [24.5 (23-27) 26 (24-28) kg/m2] CCI scores (0 vs 1), lower total testosterone [4.5 (3.4-5.6) 4.2 (3.1-5.5)] concentration [8.0 (1.5-25.0) 12 (2.8-30)], but higher DFI [38.2 (23-54) 28.0 (18-48)] presented proportion NOA (24.8% 16.3%) (all p<0.01). multivariable analysis, at risk [OR 1.78 (CI: 1.1-2.8)] DFI>30 1.92 1.2-2.9)], accounting patient age, CCI, FSH values, testicular volume. CONCLUSIONS: Patients showed worse clinical, parameters compared those values. represents reliable real-life setting, thus supporting an easier long-term follow-up patients chronic dysmetabolic comorbidities. Source Funding: None © 2021 American Urological Association Education Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e530-e530 Advertisement Copyright Permissions© Inc.MetricsAuthor Information Expand Loading ...