Pd(II)-Catalyzed C–H Functionalizations Directed by Distal Weakly Coordinating Functional Groups

نویسندگان
چکیده

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Broad-Scope Rh-Catalyzed Inverse-Sonogashira Reaction Directed by Weakly Coordinating Groups

We report the alkynylation of C(sp2)-H bonds with bromoalkynes (inverse-Sonogashira reaction) directed by synthetically useful ester, ketone, and ether groups under rhodium catalysis. Other less common directing groups such as amine, thioether, sulfoxide, sulfone, phenol ester, and carbamate are also suitable directing groups. Mechanistic studies indicate that the reaction proceeds by a turnove...

متن کامل

Construction of tetrahydrofurans by PdII/PdIV-catalyzed aminooxygenation of alkenes.

Catalytic transformations involving Pd s-alkyl or s-aryl intermediates are widely used in organic synthesis and offer attractive routes to many valuable products. However, the vast majority of these reactions proceed by Pd/Pd mechanisms. As a result, the diversity of structures/bonds that can be constructed is constrained by the limitations of this redox cycle. Recent studies have explored the ...

متن کامل

The Evolution of Pd0/PdII-Catalyzed Aromatic Fluorination

Aromatic fluorides are prevalent in both agrochemical and pharmaceutical agents. However, methods for their rapid and general preparation from widely available starting materials are limited. Traditional approaches such as the Balz-Schiemann and Halex reactions require harsh conditions that limit functional group tolerance and substrate scope. The use of transition metals to affect C-F bond for...

متن کامل

Bypassing the Limitations of Directed C–H Functionalizations of Heterocycles

In directed C–H activation reactions, nitrogen and sulfur atoms present in heterocyclic substrates coordinate strongly with metal catalysts. This coordination, which can lead to catalyst poisoning or C–H functionalization at an undesired position, limits the application of C–H activation reactions in heterocycle-based drug discovery.1–5 Herein, we report a robust and synthetically useful reacti...

متن کامل

Weakly Amenable Groups

In the present paper we construct the first examples of finitely generated non–amenable groups whose left regular representations are not uniformly isolated from the trivial representation.

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Journal of the American Chemical Society

سال: 2015

ISSN: 0002-7863,1520-5126

DOI: 10.1021/ja5126897