PDZRN3 protects against apoptosis in myoblasts by maintaining cyclin A2 expression
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چکیده
منابع مشابه
Rapamycin protects testes against germ cell apoptosis and oxidative stress induced by testicular ischemia-reperfusion
Objective(s):Rapamycin is an immunosuppressant compound with a broad spectrum of pharmaco-logical activities. In recent years, it has been used successfully to decrease ischemia-reperfusion injury in several organ systems. The purpose of the present study was to examine the effect of rapamycin on testicular ischemia-reperfusion injury. Materials and Methods: Seventy-two adult male Wistar rats w...
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Apoptosis occurs concurrently with differentiation of muscle progenitor cells (MPCs) before they fuse to form myotubes. Dysregulated apoptosis in MPCs contributes to the low regeneration capability in aged muscle and decreases the survival rate of donor cells in stem cellbased therapies for muscular dystrophies. This study investigated the role of the M-cadherin/PI3K/Akt/GSK-3b signaling pathwa...
متن کاملSuppression of GSK-3β activation by M-cadherin protects myoblasts against mitochondria-associated apoptosis during myogenic differentiation.
Apoptosis occurs concurrently with differentiation of muscle progenitor cells (MPCs) before they fuse to form myotubes. Dysregulated apoptosis in MPCs contributes to the low regeneration capability in aged muscle and decreases the survival rate of donor cells in stem cell-based therapies for muscular dystrophies. This study investigated the role of the M-cadherin/PI3K/Akt/GSK-3β signaling pathw...
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The amyloidb peptide (A b ) can mediate cell attachment by binding to b 1 integrins through an arg-his-asp sequence. We show here that the a 5 b 1 integrin, a fibronectin receptor, is an efficient binder of A b , and mediates cell attachment to nonfibrillar A b . Cells engineered to express a 5 b 1 internalized and degraded more added A b 1-40 than did a 5 b 1-negative control cells. Deposition...
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BACKGROUND Ibutilide, a class III antiarrhythmic agent has been shown to be cardioprotective in treating atrial fibrillation, promoting cardioconversion and recently this agent has been shown to protect against ER stress induced apoptosis in cardiomyocytes. In this study we begin to identify the mechanism by which ibutilide exerts its cardioprotection in tunicamycin treated cardiomyocytes. We e...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2020
ISSN: 2045-2322
DOI: 10.1038/s41598-020-58116-1