Peanut-Specific IgA and IgG4 in Saliva are Modulated by Peanut OIT

A new OIT protocol for severe peanut allergy

Methods Our pirmary outcome was the increase in the amount of ingested peanut protein tolerated in DBPCFC by peanut OIT. Secondarily we investigated safety of OIT. Since September 2011, peanut-sensitized patients with moderate to severe allergic reaction (1) in DBPCFC were included. Bronchial hyperreactivity, exhaled nitric oxide, and food allergy related quality of life (2, 3) were evaluated p...

T cell specific and non specific tolerance mechanisms in peanut oil immunotherapy in peanut allergic subjects

Rationale Our main focus in the laboratory is to understanding the mechanisms of how oral immunotherapy (OIT) improves outcomes in patients. In this study, we aimed to determine if OIT is specific only to the food allergens administered in OIT or also to other offending allergens (i.e. “bystander effect”). To accomplish our aim, we studied T cell reactivity (i.e. proliferation assays) and T cel...

Peanut panallergen Ara h 8 IgE and IgG4 epitopes

Peanut avoidance and peanut allergy diagnosis in siblings of peanut allergic children.

BACKGROUND Studies suggest that siblings of children with peanut allergy (PNA) have a higher prevalence of PNA than the general population. OBJECTIVES The Canadian Peanut Allergy Registry was used to assess the percentage of siblings of registered index PNA children who were 1) never exposed to peanut or 2) reportedly diagnosed with PNA by a physician without either a history of allergic reac...

Flavor and antioxidant capacity of peanut paste and peanut butter supplemented with peanut skins.

UNLABELLED Peanut skins (PS) are a good source of phenolic compounds. This study evaluated antioxidant properties and flavor of peanut paste and peanut butter enhanced with peanut skins. PS were added to both materials in concentrations of 0.0%, 0.5%, 1.0%, 5.0%, 10.0%, 15.0%, and 20.0% (w/w). PS, peanut paste, and peanut butter used in the study had initial total phenolics contents of 158, 12....