PECAN: library-free peptide detection for data-independent acquisition tandem mass spectrometry data
نویسندگان
چکیده
منابع مشابه
Quality classification of tandem mass spectrometry data
UNLABELLED Peptide identification by tandem mass spectrometry is an important tool in proteomic research. Powerful identification programs exist, such as SEQUEST, ProICAT and Mascot, which can relate experimental spectra to the theoretical ones derived from protein databases, thus removing much of the manual input needed in the identification process. However, the time-consuming validation of t...
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متن کاملComparison of probability and likelihood models for peptide identification from tandem mass spectrometry data.
We evaluate statistical models used in two-hypothesis tests for identifying peptides from tandem mass spectrometry data. The null hypothesis H(0), that a peptide matches a spectrum by chance, requires information on the probability of by-chance matches between peptide fragments and peaks in the spectrum. Likewise, the alternate hypothesis H(A), that the spectrum is due to a particular peptide, ...
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ژورنال
عنوان ژورنال: Nature Methods
سال: 2017
ISSN: 1548-7091,1548-7105
DOI: 10.1038/nmeth.4390