Pendrin Function in Airway Epithelia

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Thick airway surface liquid volume and weak mucin expression in pendrin-deficient human airway epithelia

Pendrin is an anion exchanger whose mutations are known to cause hearing loss. However, recent data support the linkage between pendrin expression and airway diseases, such as asthma. To evaluate the role of pendrin in the regulation of the airway surface liquid (ASL) volume and mucin expression, we investigated the function and expression of pendrin and ion channels and anion exchangers. Human...

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ژورنال

عنوان ژورنال: Cellular Physiology and Biochemistry

سال: 2011

ISSN: 1421-9778,1015-8987

DOI: 10.1159/000335115