Perivascular Adipose Tissue, Vascular Reactivity and Hypertension
نویسندگان
چکیده
منابع مشابه
Perivascular adipose tissue, vascular reactivity and hypertension.
Most blood vessels are surrounded by a variable amount of adventitial adipose tissue, perivascular adipose tissue (PVAT), which was originally thought to provide mechanical support for the vessel. It is now known that PVAT secretes a number of bioactive substances including vascular endothelial growth factor, tumor necrosis factor-alpha (TNF-α), leptin, adiponectin, insulin-like growth factor, ...
متن کاملPerivascular adipose tissue and coronary vascular disease.
Coronary perivascular adipose tissue is a naturally occurring adipose tissue depot that normally surrounds the major coronary arteries on the surface of the heart. Although originally thought to promote vascular health and integrity, there is a growing body of evidence to support that coronary perivascular adipose tissue displays a distinct phenotype relative to other adipose depots and is capa...
متن کاملParadoxical roles of perivascular adipose tissue in atherosclerosis and hypertension.
Perivascular adipose tissue (PVAT) is the fat tissue surrounding most of the vasculature and it has long been considered solely as vessel-supporting connective tissue. There are 2 major types of adipose tissue widely distributed throughout the body: white (WAT) and brown (BAT). PVAT is similar to BAT in rodents, but it was believed that only WAT existed in adult humans and BAT was present only ...
متن کاملPerivascular adipose tissue, potassium channels, and vascular dysfunction.
Perivascular adipose tissue has been recognized unequivocally as a major player in the pathology of metabolic and cardiovascular diseases. Through its production of adipokines and the release of other thus far unidentified factors, this recently discovered adipose tissue modulates vascular regulation and the myogenic response. After the discovery of its ability to diminish the vessel's response...
متن کاملRole of perivascular adipose tissue-derived methyl palmitate in vascular tone regulation and pathogenesis of hypertension.
BACKGROUND Perivascular adipose tissue (PVAT)-derived relaxing factor (PVATRF) significantly regulates vascular tone. Its chemical nature remains unknown. We determined whether palmitic acid methyl ester (PAME) was the PVATRF and whether its release and/or vasorelaxing activity decreased in hypertension. METHODS AND RESULTS Using superfusion bioassay cascade technique, tissue bath myography, ...
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ژورنال
عنوان ژورنال: Medical Principles and Practice
سال: 2015
ISSN: 1423-0151,1011-7571
DOI: 10.1159/000356380