Persistent Inflammation, Immunosuppression, and Catabolism: Evolution of Multiple Organ Dysfunction
نویسندگان
چکیده
منابع مشابه
Persistent Inflammation, Immunosuppression, and Catabolism: Evolution of Multiple Organ Dysfunction.
BACKGROUND Multiple organ dysfunction (MOD) has plagued intensive care units (ICUs) for more than four decades, and its epidemiology has evolved because more patients are surviving previously lethal insults. Over the years, different predominant phenotypes of MOD have been described, all of which have consumed tremendous healthcare resources and have been associated with prolonged ICU stays and...
متن کاملInnate Immunity in the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome and Its Implications for Therapy
Citation: Horiguchi H, Loftus TJ, Hawkins RB, Raymond SL, Stortz JA, Hollen MK, Weiss BP, Miller ES, Bihorac A, Larson SD, Mohr AM, Brakenridge SC, Tsujimoto H, Ueno H, Moore FA, Moldawer LL, Efron PA and The Sepsis and Critical Illness Research Center Investigators (2018) Innate Immunity in the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome and Its Implications for Therapy...
متن کاملInflammation, coagulopathy, and the pathogenesis of multiple organ dysfunction syndrome.
OBJECTIVE An improved understanding of the mechanisms through which infecting pathogens harm the host is leading to new formulations of the concept of sepsis. We review the roles of inflammation and coagulation in the pathogenesis of the multiple organ dysfunction syndrome, and explore the potential of new therapies to restore the fine biological balance between procoagulant and anticoagulant m...
متن کاملThe evolution and therapy aspects in multiple organ dysfunction sepsis
Background Severe sepsis was the subject of intense debate over the years, and in the last twenty years there has been a constant effort to identify therapies that reduce mortality. Although the inflammatory response is often adapted to the etiologic agent and to the increase of the mediators in association with organ dysfunction, it is not currently possible to rapidly assess the patients’ abi...
متن کاملThe Relationship between Plasma Levels of Interleukin-6, Multiple Organ Dysfunction and Mortality in Orthopedic Patients
Background: Interleukin 6 (IL-6) functions as both a pro-inflammatory cytokine and an anti-inflammatory cytokine. Objective: To evaluate the levels of IL-6 in patients with multiple organ dysfunction syndrome (MODS). Methods: Level of IL-6 was assessed and recorded for 14 days subsequent to the injury in 161 multiple trauma patients. MODS were diagnosed using Marshal Score. Injury Severity Scor...
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ژورنال
عنوان ژورنال: Surgical Infections
سال: 2016
ISSN: 1096-2964,1557-8674
DOI: 10.1089/sur.2015.184