Persistent prelimbic cortex activity contributes to enhanced learned fear expression in females
نویسندگان
چکیده
منابع مشابه
Persistent prelimbic cortex activity contributes to enhanced learned fear expression in females.
Anxiety disorders, such as post-traumatic stress, are more prevalent in women and are characterized by impaired inhibition of learned fear and medial prefrontal cortex (mPFC) dysfunction. Here we examined sex differences in fear extinction and mPFC activity in rats. Females showed more learned fear expression during extinction and its recall, but not fear conditioning. They also showed more spo...
متن کاملActivity in prelimbic cortex subserves fear memory reconsolidation over time.
The prelimbic cortex has been implicated in the consolidation of previously learned fear. Herein, we report that temporarily inactivating this medial prefrontal cortex subregion with the GABAA agonist muscimol (4.0 nmol in 0.2 μL per hemisphere) was able to equally disrupt 1-, 7-, and 21-d-old contextual fear memories after their brief retrieval in rats. In all cases, this effect was prevented ...
متن کاملThe prelimbic cortex is critical for context-dependent fear expression
The ability to regulate emotional responses in various circumstances would provide adaptive advantages for an individual. Using a context-dependent fear discrimination (CDFD) task in which the tone conditioned stimulus (CS) is paired with the footshock unconditioned stimulus (US) in one context but presented alone in another context, we investigated the role of the prelimbic (PL) cortex in cont...
متن کاملActivity in prelimbic cortex is necessary for the expression of learned, but not innate, fears.
The amygdala has long been considered to be both necessary and sufficient for classical fear conditioning, but recent evidence suggests that the medial prefrontal cortex (mPFC) may also be involved. The prelimbic (PL) subregion of mPFC projects to the amygdala, and neurons in PL show fear-related increases in activity. It is unknown, however, whether PL activity is necessary for expression of l...
متن کاملEffects of chronic stress in adolescence on learned fear, anxiety, and synaptic transmission in the rat prelimbic cortex.
The prelimbic cortex and amygdala regulate the extinction of conditioned fear and anxiety, respectively. In adult rats, chronic stress affects the dendritic morphology of these brain areas, slowing extinction of learned fear and enhancing anxiety. The aim of this study was to determine whether rats subjected to chronic stress in adolescence show changes in learned fear, anxiety, and synaptic tr...
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ژورنال
عنوان ژورنال: Learning & Memory
سال: 2014
ISSN: 1072-0502,1549-5485
DOI: 10.1101/lm.033514.113