Personalizing Androgen Suppression for Prostate Cancer Using Mathematical Modeling

Personalizing Androgen Suppression for Prostate Cancer Using Mathematical Modeling

Using a dataset of 150 patients treated with intermittent androgen suppression (IAS) through a fixed treatment schedule, we retrospectively designed a personalized treatment schedule mathematically for each patient. We estimated 100 sets of parameter values for each patient by randomly resampling each patient's time points to take into account the uncertainty for observations of prostate specif...

Quantitative mathematical modeling of PSA dynamics of prostate cancer patients treated with intermittent androgen suppression.

If a mathematical model is to be used in the diagnosis, treatment, or prognosis of a disease, it must describe the inherent quantitative dynamics of the state. An ideal candidate disease is prostate cancer owing to the fact that it is characterized by an excellent biomarker, prostate-specific antigen (PSA), and also by a predictable response to treatment in the form of androgen suppression ther...

Mathematical Models of Androgen Resistance in Prostate Cancer Patients under Intermittent Androgen Suppression Therapy

Predicting the timing of a castrate resistant prostate cancer is critical to lowering medical costs and improving the quality of life of advanced prostate cancer patients. We formulate, compare and analyze two mathematical models that aim to forecast future levels of prostate-specific antigen (PSA). We accomplish these tasks by employing clinical data of locally advanced prostate cancer patient...

A Mathematical Model of Intermittent Androgen Suppression Remedy for Prostate Cancer

Androgen suppression has been the principal modality for treatment of advanced prostate cancer for several decades. Although the tumor response rate to androgen deprivation is initially high, almost all patients relapse within several years due to proliferation of androgenindependent tumor cells. Since Bruchovsky et al. suggested in animal models that intermittent androgen suppression can prolo...

Mathematical modeling in immunotherapy of cancer: personalizing clinical trials.