Perspectives series: host/pathogen interactions. Apoptosis in bacterial pathogenesis.
نویسندگان
چکیده
منابع مشابه
Perspectives Series: Host/Pathogen Interactions
A pathogen has the ability to access a privileged niche within a host. Pathogens often cause direct or indirect host cell damage to gain access to this niche, and most pathogenic species have characteristic attributes to interact with, or stay in very close proximity to, a precise cell type. Commensals and opportunists cause infections as well if they are introduced into a privileged site or if...
متن کاملPerspectives Series: Host/Pathogen Interactions
Mucosal surfaces of the intestinal, respiratory, and genitourinary tracts are the most important route of entry of microbial pathogens into the host, and are important sites of microbially induced disease. Mucosal infections with microbial pathogens can result in a spectrum of disease manifestations that range from mild and self-limited to fulminant and lethal, or can be chronic and debilitatin...
متن کاملPerspectives Series: Host/Pathogen Interactions
The threat posed to human health by arthropod-borne bacteria is most vividly demonstrated by the devastating epidemics caused by the plague. The diversity of pathogenic bacteria spread by arthropods is probably underestimated. Recently recognized infectious diseases such as Lyme disease and ehrlichiosis are caused by bacteria transmitted by arthropods. Bacteria which alternate between arthropod...
متن کاملPerspectives Series: Host/Pathogen Interactions
Increasing numbers of bacterial pathogens have been identified as mediators of apoptosis in vitro (1, 2). These pathogens infect many different tissues and include gram-positive and -negative bacteria as well as Mycobacteria . In this review, we analyze the role of apoptosis in bacterial pathogenesis. At least three pathogenic strategies involve programmed cell death: activation of apoptosis to...
متن کاملPerspectives Series: Host/Pathogen Interactions
The high plasticity of the actin cytoskeleton and its dynamics are often exploited by bacterial pathogens, during entry, and in some cases movement and dissemination of these organisms in mammalian cells. Indeed, some bacterial pathogens, including the gram-negative bacteria Salmonella , Shigella , and Yersinia and the gram-positive bacterium Listeria monocytogenes , have the capacity to induce...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1997
ISSN: 0021-9738
DOI: 10.1172/jci119557