pH-responsive and enzymatically-responsive hydrogel microparticles for the oral delivery of therapeutic proteins: Effects of protein size, crosslinking density, and hydrogel degradation on protein delivery
نویسندگان
چکیده
منابع مشابه
Stimuli-responsive Hydrogel for Drug Delivery
Introduction Hydrogels have been extensively investigated as drug delivery carriers in biomedical applications.The stimuli-responsive hydrogel is generally created when an ionic monomer is incorporated into the hydrogel network, in which the charged group is formed and called fixed charge since its mobility is much less than that of freely mobile ions within the interstitial fluid. In this stud...
متن کاملDesign of a Versatile pH-Responsive Hydrogel for Potential Oral Delivery of Gastric-Sensitive Bioactives
A pH-responsive hydrogel system was prepared by free radical polymerization of acrylamide and methyl acrylic acid in the presence of N-N′-methylene bisacrylamide. Sodium bicarbonate was further applied as a blowing agent, which afforded a porous hydrogel structure. The hydrogel system achieved a constant super swelling rate within simulated intestinal buffer (~4%/min) and remained relatively st...
متن کاملpH-Responsive Hydrogel with Controlled Swelling and Degradation Rate
A range of hydrogels were prepared by solution polymerization of methacrylic acid, poly(ethyleneglycol) methyl ether methacrylate (M.W. 475 g/mol) and poly(ethyleneglycol) dimethacrylate (as the cross-linking, M.W. 550 or 875 g/mol) in various proportions. The effects of methacrylic acid/ poly(ethyleneglycol) methyl ether methacylate concentration ratios as well as cross-linking concentration i...
متن کامل: the effect of sericin levels (silk glue protein) on rate of in vitro maturation, fertilization and culture of sheep oocytes
هدف از آزمایش اول بررسی اثر سطوح مختلف سریسین [0 (control), 0.1, 0.5, 1.0, 2.5 %] افزوده شده به محیط , ivm بر cumulus cell expansion، بلوغ هسته و توسعه متوالی جنین، در گوسفندان نژاد سنجابی در فصل تولید مثلی می باشد. از سرگیری میوز به وسیله خارج شدن اولین پولار بادی اندازه گیری و هم چنین درصد رسیدن جنین های دو سلولی به مرحله کلیواژ و بلاستوسیت نیز به عنوان نشانه ای از میزان شایستگی توسعه اولیه ج...
Dual pH- and temperature-responsive microparticles for protein delivery to ischemic tissues.
Injectable "smart" microspheres that are sensitive to both temperature and pH have been fabricated and tested for controlled delivery of therapeutic proteins to ischemic skeletal muscle. A library of copolymers composed of N-isopropyl acrylamide (NIPAAm), propyl acrylic acid (PAA), and butyl acrylate (BA) was used to fabricate microspheres using a double emulsion method, and an optimal formulat...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Controlled Release
سال: 2016
ISSN: 0168-3659
DOI: 10.1016/j.jconrel.2015.11.023