pH-triggered peptide self-assembly into fibrils: a potential peptide-based subunit vaccine delivery platform
نویسندگان
چکیده
منابع مشابه
Peptide-Based Subunit Vaccine against Hookworm Infection
Hookworms infect more people than HIV and malaria combined, predominantly in third world countries. Treatment of infection with chemotherapy can have limited efficacy and re-infections after treatment are common. Heavy infection often leads to debilitating diseases. All these factors suggest an urgent need for development of vaccine. In an attempt to develop a vaccine targeting the major human ...
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Peptide and protein drugs have found an important position in therapeutics. Recent advances in pharmaceutical biotechnology have led to an increase in the number of protein products in the market. As these therapeutic proteins and peptides are made available, it will be essential to formulate these drugs into safe and effective delivery systems. The twenty different naturally occurring amin...
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We report the synthesis of a series of anionic dendritic peptide amphiphiles of increasing hydrophobic character. By establishing state diagrams we describe their pH and ionic strength triggered self-assembly into supramolecular nanorods in water and highlight the impact of hydrophobic shielding in the supramolecular polymerisation process. Via the incorporation of fluorinated peptide side chai...
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Self-assembling systems present attractive platforms for engineering stimulus-responsive materials with controlled nanoand microstructures. Recent efforts to design such systems include synthetic block copolymers,1a proteins that self-assemble into hydrogels via leucine zipper motifs,1b cyclic peptides that selfassemble into nanotubes,1c-e and peptides that form fibrillar â-sheet networks.1f-i ...
متن کاملPeptide and Protein Delivery at a Glance
Peptide and protein drugs have found an important position in therapeutics. Recent advances in pharmaceutical biotechnology have led to an increase in the number of protein products in the market. As these therapeutic proteins and peptides are made available, it will be essential to formulate these drugs into safe and effective delivery systems. The twenty different naturally occurring amin...
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ژورنال
عنوان ژورنال: Biochemical Compounds
سال: 2013
ISSN: 2052-9341
DOI: 10.7243/2052-9341-1-2