Pharmacologic and Clinical Considerations of Nalmefene, a Long Duration Opioid Antagonist, in Opioid Overdose
نویسندگان
چکیده
Opioid use disorder is a well-established and growing problem in the United States. It responsible for both psychosocial physical damage to affected individuals with significant mortality rate. Given medical non-medical consequences of this epidemic, it important understand current treatments approaches opioid acute overdose. Naloxone competitive mu-opioid receptor antagonist that used reversal intoxication. When given intravenously, naloxone has an onset action approximately 2 min duration 60–90 min. Related its empirical dosing short action, frequent monitoring patient required so effects toxicity, namely respiratory depression, do not return wreak havoc. Nalmefene pure structurally similar naltrexone can serve as alternative antidote reversing depression associated also known 6-methylene naltrexone. Its main features interest are prolonged surpasses most opioids ability This be pivotal reducing healthcare costs, increasing satisfaction, redistributing time staff spend overdose patients naloxone.
منابع مشابه
In vivo characterization of the opioid antagonist nalmefene in mice.
AIMS The current study assessed the in vivo antagonist properties of nalmefene using procedures previously used to characterize the opioid antagonists naloxone, naltrexone, 6beta-naltrexol and nalbuphine. MAIN METHODS ICR mice were used to generate antagonist dose-response curves with intraperitoneal (i.p.) nalmefene against fixed A(90) doses of morphine in models of morphine-stimulated hyper...
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ژورنال
عنوان ژورنال: Psychiatry international
سال: 2021
ISSN: ['2673-5318']
DOI: https://doi.org/10.3390/psychiatryint2040028