Pharmacological properties of the Cys23Ser single nucleotide polymorphism in human 5-HT2C receptor isoforms
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چکیده
منابع مشابه
5-HT2C receptor agonists: pharmacological characteristics and therapeutic potential.
In vitro, (S)-2-(chloro-5-fluoro-indol-1-yl)-1-methylethylamine 1:1 C4H4O4 and (S)-2-(4,4,7-trimethyl-1,4-dihydro-indeno[1, 2-b]pyrrol-1-yl)-1-methylethylamine 1:1 C4H4O4 exhibited high-affinity binding to the serotonin2C (5HT2C) receptors and stimulated turnover of inositol 1,4,5-triphosphate. Affinity to several of the other 5-HT receptor subtypes and to numerous nonserotonergic receptors was...
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Extended Abstract Introduction and Objective: Varroa infestation is undoubtedly the greatest threat and challenge facing Apiculture today. This external parasite inevitably lives in the bee colony and causes irreparable damage to its colony and the subsequent honey production. One of the proposed strategies in this regard is the use of pesticides, which have a negative impact on the health of ...
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It has been postulated that the persistent short intravaginal ejaculation latency time (IELT) of men with lifelong premature ejaculation (LPE) is related to 5-hydroxytryptamine (HT)2C receptor functioning. The aim of this study was to investigate the relationship of Cys23Ser 5-HT2C receptor gene polymorphism and the duration of IELT in men with LPE. Therefore, a prospective study was conducted ...
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The human 5-hydroxytryptamine-2C (5-HT2C) receptor has been the target of potential anxiolytics and antiobesity drugs, and its positive allosteric modulator was discovered to be l-threo-alpha-d-galacto-octopyranoside, methyl-7-chloro-6,7,8-trideoxy-6-[[(4-undecyl-2-piperidinyl)carbonyl]amino]-1-thiomonohydrochloride (2S-cis) (PNU-69176E). The drug at low micromolar concentrations (<25 microM) m...
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ژورنال
عنوان ژورنال: The Pharmacogenomics Journal
سال: 2005
ISSN: 1470-269X,1473-1150
DOI: 10.1038/sj.tpj.6500315