Pharmacological targeting of adenosine receptor signaling
نویسندگان
چکیده
منابع مشابه
Targeting Adenosine Signaling in Parkinson's Disease: From Pharmacological to Non-pharmacological Approaches
Parkinson's disease (PD) is one of the most prevalent neurodegenerative disease displaying negative impacts on both the health and social ability of patients and considerable economical costs. The classical anti-parkinsonian drugs based in dopaminergic replacement are the standard treatment, but several motor side effects emerge during long-term use. This mini-review presents the rationale to s...
متن کاملRole of Adenosine receptor in lung cancer
Summary: Adenosine through adenosine receptor have a crucial role in biology of lung cancer. Recent study indicated adenosine receptors have a crucial role in various aspect of lung cancer from cell growth and metastasis to modulation of apoptosis and it could be considered as a potential candidate for treatment of the lung cancer.
متن کاملPharmacological preconditioning with resveratrol: role of CREB-dependent Bcl-2 signaling via adenosine A3 receptor activation.
Recent studies demonstrated that resveratrol, a grape-derived polyphenolic phytoalexin, provides pharmacological preconditioning (PC) of the heart through a NO-dependent mechanism. Because adenosine receptors play a role in PC, we examined whether they play any role in resveratrol PC. Rats were randomly assigned to groups perfused for 15 min with 1) Krebs-Henseleit bicarbonate buffer (KHB) only...
متن کاملPharmacological Preconditioning with Resveratrol: a Role of Creb-dependent Bcl-2- Signaling via Adenosine A3 Receptor Activation
Recent studies demonstrated that resveratrol, a grape-derived polyphenolic phytoalexin, could pharmacologically precondition (PC) the heart through a nitric oxide (NO)-dependent mechanism. Since, adenosine receptors have been found to play a role in PC, this study examined if adenosine receptors could play any role in resveratrol PC. The rats were randomly assigned to one of the following group...
متن کاملEstrogen receptor-β expression and pharmacological targeting in bladder cancer
A role for estrogen signaling in urothelial carcinoma of the bladder (UCB) is suggested to be associated with more advanced disease with worse outcomes in women. Estrogen receptor β (ERβ) is the predominant receptor in bladder tissues. We aimed to ascertain whether ERβ correlates with clinicopathological predictors of aggressive bladder cancer and worse survival outcomes. ERβ was measured by im...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Aspects of Medicine
سال: 2017
ISSN: 0098-2997
DOI: 10.1016/j.mam.2016.12.002