Phenotypic characterization of human decidual macrophages

Phenotypic Characterization of Human Intermediate Monocytes

A full understanding of the immune system requires full characterization of the cells, and its subsets, which play a role in the process of host defense. The expression pattern of cell surface molecules serves as a major criterion for assigning cells into discrete subsets. The availability of monoclonal reagents, specific fluorescent probes and compatible instrumentation over the past years has...

Gene Expression Profiling of Human Decidual Macrophages: Evidence for Immunosuppressive Phenotype

BACKGROUND Although uterine macrophages are thought to play an important regulatory role at the maternal-fetal interface, their global gene expression profile is not known. METHODOLOGY/PRINCIPAL FINDINGS Using micro-array comprising approximately 14,000 genes, the gene expression pattern of human first trimester decidual CD14+ monocytes/macrophages was characterized and compared with the expr...

Role of decidual natural killer cells & macrophages in pre-eclampsia

Number of decidual natural killer cells & macrophages in pre-eclampsia

BACKGROUND & OBJECTIVES The process of human placentation is complex and still not well understood. This study was aimed to examine the relationship between clinical features of pre-eclampsia and degree of trophoblastic invasion after its immunohistochemical visualization in the context of possible alterations in the number of natural killer (NK) cells and macrophages in the decidua. METHODS ...

Two Unique Human Decidual Macrophage