Phenotyping of human complement component C4, a class-III HLA antigen
نویسندگان
چکیده
منابع مشابه
ULCERATIVE COLITIS AND HLA CLASS II PHENOTYPING IN IRAN
Ulcerative colitis (UC) is a nonspecific acute and chronic inflammatory bowel disease that diffusely involves the colonic mucosa. The etiology of UC has not yet been elucidated fully. However, many studies have found that immunologic disorders may play a role in the pathogenesis of UC. In addition, due to an increased frequency of UC in families, especially an increased monozygotic compared...
متن کاملEffect of thiol compounds on human complement component C4.
Thiol compounds have been investigated as inhibitors of the covalent binding reaction of human complement protein C4 using Sepharose-C1s as a combined activating and binding surface. o- and p-substituted aminothiophenols are equally effective inhibitors, whereas the m-substituted compound is a less potent inhibitor. The anti-hypertensive drug captopril is also shown to inhibit the covalent bind...
متن کاملThe complement component C4 of mammals.
Human complement component C4 is coded by tandem genes located in the HLA class III region. The products of the two genes, C4A and C4B, are different in their activity. This difference is due to a degree of 'substrate' specificity in the covalent binding reactions of the two isotypes. Mouse also has a duplicated locus, but only one gene produces active C4, while the other codes for the closely ...
متن کاملulcerative colitis and hla class ii phenotyping in iran
ulcerative colitis (uc) is a nonspecific acute and chronic inflammatory bowel disease that diffusely involves the colonic mucosa. the etiology of uc has not yet been elucidated fully. however, many studies have found that immunologic disorders may play a role in the pathogenesis of uc. in addition, due to an increased frequency of uc in families, especially an increased monozygotic compared wit...
متن کاملTaqI RFLP polymorphism of the ovine complement component C4 gene.
Protocol: Reactions were performed as described (2) using 1 ng of DNA and 100 pmoles of each primer. DNA was amplified for 20 cycles using a Perkin Elmer Cetus DNA Thermal Cycler: denaturation, 94°C, 1 min; annealing, 60°C, 1 min; and extension, 70°C, 1.5 min. Ten /il of the reaction was analyzed directly on a 2.5 % NuSieve GTG agarose gel run in Tns-borate buffer. The amplified DNA fragments v...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1986
ISSN: 0264-6021,1470-8728
DOI: 10.1042/bj2390763