Phosphatidylserine externalization during differentiation-triggered apoptosis of erythroleukemic cells
نویسندگان
چکیده
منابع مشابه
Suicidal membrane repair regulates phosphatidylserine externalization during apoptosis.
One of the hallmarks of apoptosis is the redistribution of phosphatidylserine (PS) from the inner-to-outer plasma membrane (PM) leaflet, where it functions as a ligand for phagocyte recognition and the suppression of inflammatory responses. The mechanism by which apoptotic cells externalize PS has been assumed to involve "scramblases" that randomize phospholipids across the PM bilayer. These pu...
متن کاملNADPH Oxidase-dependent Oxidation and Externalization of Phosphatidylserine during Apoptosis in Me2SO-differentiated HL-60 Cells
From the Department of Environmental and Occupational Health, Department of Pharmacology, and Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, the Magee-Womens Research Institute, Pittsburgh, Pennsylvania 15213, the Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg 194223, Russia, the Department of Medical Ch...
متن کاملPhospholipid signaling in apoptosis: peroxidation and externalization of phosphatidylserine.
The role of phospholipids in apoptosis signaling and the relationship between oxidation of phosphatidylserine and its redistribution in the plasma membrane were studied. A novel method for detection of site-specific phospholipid peroxidation based on the use of cis-parinaric acid as a reporter molecule metabolically integrated into membrane phospholipids in living cells was employed. When sever...
متن کاملPhosphatidylserine externalization, “necroptotic bodies” release, and phagocytosis during necroptosis
Necroptosis is a regulated, nonapoptotic form of cell death initiated by receptor-interacting protein kinase-3 (RIPK3) and mixed lineage kinase domain-like (MLKL) proteins. It is considered to be a form of regulated necrosis, and, by lacking the "find me" and "eat me" signals that are a feature of apoptosis, necroptosis is considered to be inflammatory. One such "eat me" signal observed during ...
متن کاملCaspase-mediated activation of Caenorhabditis elegans CED-8 promotes apoptosis and phosphatidylserine externalization
During apoptosis, phosphatidylserine (PS), normally restricted to the inner leaflet of the plasma membrane, is exposed on the surface of apoptotic cells and serves as an ‘eat-me’ signal to trigger phagocytosis. It is poorly understood how PS exposure is activated in apoptotic cells. Here we report that CED-8, a Caenorhabditis elegans protein implicated in controlling the kinetics of apoptosis a...
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ژورنال
عنوان ژورنال: Cell Death & Differentiation
سال: 1999
ISSN: 1350-9047,1476-5403
DOI: 10.1038/sj.cdd.4400484