Phosphatidylserine Reversibly Binds Cu2+with Extremely High Affinity

Phosphatidylserine and Opsonizes Urokinase High Molecular Weight Kininogen Binds

Letter: Increased hemoglobin-oxygen affinity at extremely high altitudes.

Eaton et al. (1) stated that "increased, rather than decreased, oxygen affinity is an effective mode of short-term adaptation to markedly reduced environmental oxygen pressures" and pointed out the need to reevaluate the idea that "decreased hemoglobin-oxygen affinity is of adaptive value to humans at high altitudes." We fully agree with these authors and wish to call attention to the fact that...

Thrombospondin-1 binds to polyhistidine with high affinity and specificity.

Thrombospondin-1 (TSP1) is a secreted trimeric glycoprotein of 450 kDa with demonstrated effects on cell growth, adhesion and migration. Its complex biological activity is attributed to its ability to bind to cell-surface receptors, growth factors and extracellular-matrix proteins. In this study, we used a (125)I solid-phase binding assay to demonstrate that TSP1 binds specifically to proteins ...

Polyphosphate binds with high affinity to exosite II of thrombin.

BACKGROUND Polyphosphate (a linear polymer of inorganic phosphate) is secreted from platelet dense granules, and we recently showed that it accelerates factor V activation by thrombin. OBJECTIVE To examine the interaction of polyphosphate with thrombin. METHODS AND RESULTS Thrombin, but not prothrombin, altered the electrophoretic migration of polyphosphate in gel mobility assays. Thrombin ...

The PET Radioligand [C]MePPEP Binds Reversibly and with High Specific Signal to Cannabinoid CB1 Receptors in Nonhuman Primate Brain

Fumihiko Yasuno, Amira K Brown, Sami S Zoghbi, Joseph H Krushinski, Eyassu Chernet, Johannes Tauscher, John M Schaus, Lee A Phebus, Amy K Chesterfield, Christian C Felder, Robert L Gladding, Jinsoo Hong, Christer Halldin, Victor W Pike and Robert B Innis* Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD, USA; Lilly Research Laboratories, Lilly Corporate Center, Indian...