Phosphorylation-dependent interaction between tumor suppressors Dlg and Lgl
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چکیده
منابع مشابه
Regulation of DLG Localization at Synapses by CaMKII-Dependent Phosphorylation
Discs large (DLG) mediates the clustering of synaptic molecules. Here we demonstrate that synaptic localization of DLG itself is regulated by CaMKII. We show that DLG and CaMKII colocalize at synapses and exist in the same protein complex. Constitutively activated CaMKII phenocopied structural abnormalities of dlg mutant synapses and dramatically increased extrajunctional DLG. Decreased CaMKII ...
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Loss of cell polarity and tissue architecture are characteristics of malignant cancers derived from epithelial tissues. We provide evidence from Drosophila that a group of membrane-associated proteins act in concert to regulate both epithelial structure and cell proliferation. Scribble (Scrib) is a cell junction-localized protein required for polarization of embryonic and, as demonstrated here,...
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NIPP1 is a ubiquitously expressed nuclear protein that functions both as a regulator of protein Ser/Thr phosphatase-1 and as a splicing factor. The N-terminal part of NIPP1 consists of a phosphothreonine-interacting Forkhead-associated (FHA) domain. We show here that the FHA domain of NIPP1 interacts in vitro and in vivo with a TP dipeptide-rich fragment of the splicing factor SAP155/SF3b(155),...
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Fani Papagiannouli1 and Bernard M. Mechler2,3,4 1Cell Networks–Cluster of Excellence, Centre for Organismal Studies (COS) and BIOQUANT Center, University of Heidelberg, Heidelberg, 2Department of Cell Biology, Institute of Physiology, 1st Faculty of Medicine, Charles University, Prague, 3Deutsches Krebsforschungszentrum, Heidelberg, 4VIT-University, Vellore, Tamil Nadu, 1,3Germany 2Czech Republ...
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The junctional neoplastic tumour suppressors, Lgl, Dlg and Scrib, function in apical-basal cell polarity and limiting cell proliferation. In homozygous lgl, dlg or scrib mutants over-proliferation and polarity loss occurs in the larval imaginal disc epithelium. However, in lgl mutant mosaic eye epithelium, ectopic Cyclin E expression and cell proliferation occurs without loss of polarity. lgl m...
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ژورنال
عنوان ژورنال: Cell Research
سال: 2014
ISSN: 1001-0602,1748-7838
DOI: 10.1038/cr.2014.16