Phototriggered Sequence-specific DNA Transportation into Liposomes Using Ultrafast DNA Photocrosslinking
نویسندگان
چکیده
منابع مشابه
DNA-catalyzed sequence-specific hydrolysis of DNA
Deoxyribozymes (DNA catalysts) have been reported for cleavage of RNA phosphodiester linkages, but cleaving peptide or DNA phosphodiester linkages is much more challenging. Using in vitro selection, here we identified deoxyribozymes that sequence-specifically hydrolyze DNA with multiple turnover and with a rate enhancement of 108 (possibly as high as 1014). The new DNA catalysts require both Mn...
متن کاملImport of plasmid DNA into the nucleus is sequence specific.
Nuclear import of plasmid DNA in nondividing cells is a process essential to the success of numerous viral life cycles, gene therapy protocols, and gene expression experiments. Here, intact protein-free SV40 DNA was cytoplasmically injected into cells and its subcellular localization was followed by in situ hybridization. SV40 DNA localized to the nucleus consistent with a mechanism of transpor...
متن کاملA MODEL FOR THE BASIC HELIX- LOOPHELIX MOTIF AND ITS SEQUENCE SPECIFIC RECOGNITION OF DNA
A three dimensional model of the basic Helix-Loop-Helix motif and its sequence specific recognition of DNA is described. The basic-helix I is modeled as a continuous ?-helix because no ?-helix breaking residue is found between the basic region and the first helix. When the basic region of the two peptide monomers are aligned in the successive major groove of the cognate DNA, the hydrophobi...
متن کاملSegmenting DNA sequence into `words'
[Abstract] This paper presents a novel method to segment/decode DNA sequences based on statistical language model. Firstly, we find the length of most DNA “words” is 12 to 15 bps by analyzing the genomes of 12 model species. Then we apply the unsupervised approach to build the DNA vocabulary and design DNA sequence segmentation method. We also find different genomes is likely to use the similar...
متن کاملDNA Sequence Analysis using
Adaptive resonance theory (ART) describes a class of artiicial neural network architectures that act as classiication tools which self-organize, work in real-time, and require no retraining to classify novel sequences. We have adapted ART networks to provide support to scientists attempting to categorize tandem repeat DNA fragments from Onchocerca volvulus. In this approach, sequences of DNA fr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Chemistry Letters
سال: 2017
ISSN: 0366-7022,1348-0715
DOI: 10.1246/cl.170835