Physical Models of Mesoderm Invagination in Drosophila Embryo
نویسندگان
چکیده
منابع مشابه
Mechanical signals trigger Myosin II redistribution and mesoderm invagination in Drosophila embryos.
During Drosophila gastrulation, two waves of constriction occur in the apical ventral cells, leading to mesoderm invagination. The first constriction wave is a stochastic process mediated by the constriction of 40% of randomly positioned mesodermal cells and is controlled by the transcription factor Snail. The second constriction wave immediately follows and involves the other 60% of the mesode...
متن کاملA 3D finite element model of ventral furrow invagination in the Drosophila melanogaster embryo.
The paper describes a mechanical model of epithelial tissue development in Drosophila embryos to investigate a buckling phenomenon called invagination. The finite element method is used to model this ventral furrow formation in 3D by decomposing the total deformation into two parts: an imposed active deformation, and an elastic passive deformation superimposed onto the latter. The model imposes...
متن کاملAnalysis and reconstitution of the genetic cascade controlling early mesoderm morphogenesis in the Drosophila embryo
To understand how transcription factors direct developmental events, it is necessary to know their target or 'effector' genes whose products mediate the downstream cell biological events. Whereas loss of a single target may partially or fully recapitulate the phenotype of loss of the transcription factor, this does not mean that this target is the only direct mediator. For a complete understand...
متن کاملComputational Models for Neurogenic Gene Expression in the Drosophila Embryo
The early Drosophila embryo is emerging as a premiere model system for the computational analysis of gene regulation in development because most of the genes, and many of the associated regulatory DNAs, that control segmentation and gastrulation are known. The comprehensive elucidation of Drosophila gene networks provides an unprecedented opportunity to apply quantitative models to metazoan enh...
متن کاملCNS midline to mesoderm signaling in Drosophila
The dorsal median cells are unique mesodermal cells that reside on the surface of the ventral nerve cord in the Drosophila embryo. The Buttonless homeodomain protein is specifically expressed in these cells and is required for their differentiation. We have determined that proper buttonless gene expression and dorsal median cell differentiation requires signals from underlying CNS midline cells...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2013
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2013.05.039