Physiogenomic analysis of weight loss induced by dietary carbohydrate restriction

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Physiogenomic analysis of weight loss induced by dietary carbohydrate restriction

BACKGROUND Diets that restrict carbohydrate (CHO) have proven to be a successful dietary treatment of obesity for many people, but the degree of weight loss varies across individuals. The extent to which genetic factors associate with the magnitude of weight loss induced by CHO restriction is unknown. We examined associations among polymorphisms in candidate genes and weight loss in order to un...

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Murine weight loss exhibits significant genetic variation during dietary restriction.

We present genetic analyses of murine weight loss during dietary restriction (DR) for females eating 60% ad libitum (AL). We examined 5 cohorts across 81 different strains (22 strains tested twice) that included the LXS and LSXSS recombinant inbred strains, the LXS parental strains ILS and ISS, and the classical inbreds 129S6, A, BALB/c, C57BL/6, C3H, and DBA. Weight loss exhibited highly signi...

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Short-term weight loss and hepatic triglyceride reduction: evidence of a metabolic advantage with dietary carbohydrate restriction.

BACKGROUND Individuals with nonalcoholic fatty liver disease (NAFLD) have excess intrahepatic triglycerides. This is due, in part, to increased hepatic synthesis of fat from carbohydrates via lipogenesis. Although weight loss is currently recommended to treat NAFLD, little attention has been given to dietary carbohydrate restriction. OBJECTIVE The aim of this study was to determine the effect...

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Dietary Carbohydrate Restriction Slows Prostate Tumor Growth

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Physiogenomic comparison of human fat loss in response to diets restrictive of carbohydrate or fat

BACKGROUND Genetic factors that predict responses to diet may ultimately be used to individualize dietary recommendations. We used physiogenomics to explore associations among polymorphisms in candidate genes and changes in relative body fat (Delta%BF) to low fat and low carbohydrate diets. METHODS We assessed Delta%BF using dual energy X-ray absorptiometry (DXA) in 93 healthy adults who cons...

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ژورنال

عنوان ژورنال: Nutrition & Metabolism

سال: 2006

ISSN: 1743-7075

DOI: 10.1186/1743-7075-3-20