Physiologically‐Based Pharmacokinetic Modeling for Optimal Dosage Prediction of Quinine Coadministered With Ritonavir‐Boosted Lopinavir

Modeling for Optimal Probability Prediction

We present a general modeling method for optimal probability prediction over future observations, in which model dimensionality is determined as a natural by-product. This new method yields several estimators, and we establish theoretically that they are optimal (either overall or under stated restrictions) when the number of free parameters is infinite. As a case study, we investigate the prob...

Pharmacokinetic Modeling and Optimal Sampling Strategies for Therapeutic Drug Monitoring of Rifampin in Patients with Tuberculosis.

Rifampin, together with isoniazid, has been the backbone of the current first-line treatment of tuberculosis (TB). The ratio of the area under the concentration-time curve from 0 to 24 h (AUC0-24) to the MIC is the best predictive pharmacokinetic-pharmacodynamic parameter for determinations of efficacy. The objective of this study was to develop an optimal sampling procedure based on population...

Pharmacokinetic Evaluation of Quinine in Tablet Formulation from Herbal Extract

The rationale of this project work is to formulate oral herbal tablets of Cinchona officinalis extract containing quinine and also with pure synthetic quinine, further to determine the pharmacokinetic profile for both and compare. The concentration of quinine in the extract was estimated by HPTLC with comparison to synthetic form. Tablets were prepared from both extract and synthetic form throu...

Pharmacokinetic Parameters of Quinine in Healthy Volunteers and Patients with Uncomplicated P. falciparum Malaria after a Single Dose of Oral Quinine Sulfate Capsules PHARMACOKINETIC

CLINICAL PHARMACOLOGY Pharmacokinetics: Absorption: The oral bioavailability of quinine is 76 to 88% in healthy adults. Quinine exposure is higher in patients with malaria than in healthy subjects. After a single oral dose of quinine sulfate, the mean quinine Tmax was longer, and mean AUC and Cmax were higher in patients with uncomplicated P. falciparum malaria than in healthy subjects, as show...

Grading of Quinine Dosage to Body-Weight : Possible Economy