<p>Lambert-Eaton Myasthenic syndrome: early diagnosis is key</p>
نویسندگان
چکیده
منابع مشابه
Lambert-Eaton myasthenic syndrome.
Lambert-Eaton myasthenic syndrome (LEMS) is an idiopathic or paraneoplastic syndrome producing antibodies against presynaptic voltage-gated P/Q calcium channels. This decreases calcium entry into the presynaptic terminal, which prevents binding of vesicles to the presynaptic membrane and acetylcholine release. LEMS is most often associated with small cell lung cancer, although idiopathic presen...
متن کاملClinical presentation and differential diagnosis of Lambert-Eaton myasthenic syndrome.
Lambert-Eaton myasthenic syndrome (LEMS) is frequently associated with malignancy, especially small cell lung cancer (SCLC). Here, we describe a patient with a 5-year history of cervical myelopathy who presented with recurrent limb weakness of her limbs and complained of recent progressive weakness. Following an examination that included electromyography, a chest CT scan, and a bronchofiberscop...
متن کاملChild neurology: diagnosis of Lambert-Eaton myasthenic syndrome in children.
OBJECTIVE To report a case of Lambert-Eaton myasthenic syndrome (LEMS) in a child and review the existing literature of LEMS in children. METHODS We report a pediatric case of LEMS with the classic clinical triad of proximal weakness, autonomic dysfunction, and areflexia; the characteristic increment in compound motor action potential on high-frequency repetitive nerve stimulation; and positi...
متن کاملLambert-Eaton Myasthenic Syndrome; Pathogenesis, Diagnosis, and Therapy
Lambert-Eaton Myasthenic Syndrome (LEMS) is a rare disease with a well-characterized pathogenesis. In 50% of the patients, LEMS is a paraneoplastic manifestation and caused by a small cell lung carcinoma (SCLC). Both LEMS patients with SCLC and those without this tumour have in 85% of cases pathogenetic antibodies of very high LEMS specificity against voltage-gated calcium channels (VGCCs) in t...
متن کاملClassic diseases revisited Lambert-Eaton myasthenic syndrome
The Lambert-Eaton myasthenic syndrome is a neuromuscular disorder characterised by defective neurotransmitter release at autonomic neurones and presynaptic terminals of the neuromuscular junction. It is caused by an IgG autoantibody formed against especially the P/Q type of voltagegated calcium channels (VGCC) which is an essential component of the mechanism of neurotransmitter release. Many pa...
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ژورنال
عنوان ژورنال: Degenerative Neurological and Neuromuscular Disease
سال: 2019
ISSN: 1179-9900
DOI: 10.2147/dnnd.s192588