Plasma and Pancreatic Tissue Levels of Islet Amyloid Polypeptide in Type 1 and Type 2Diabetes: A Review

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Islet Amyloid Polypeptide is not a Target Antigen for CD8+ T-Cells in Type 2 Diabetes

Background: Type 2 diabetes (T2D) is a chronic metabolic disorder in which beta-cells are destroyed. The islet amyloid polypeptide (IAPP) produced by beta-cells has been reported to influence beta-cell destruction. Objective: To evaluate if IAPP can act as an autoantigen and therefore, to see if CD8 + T-cells specific for this protein might be present in T2D patients. Methods: Peripheral blood ...

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islet amyloid polypeptide is not a target antigen for cd8+ t-cells in type 2 diabetes

background: type 2 diabetes (t2d) is a chronic metabolic disorder in which beta-cells are destroyed. the islet amyloid polypeptide (iapp) produced by beta-cells has been reported to influence beta-cell destruction. objective: to evaluate if iapp can act as an autoantigen and therefore, to see if cd8 + t-cells specific for this protein might be present in t2d patients. methods: peripheral blood ...

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High Plasma Levels of Islet Amyloid Polypeptide in Young with New-Onset of Type 1 Diabetes Mellitus

AIMS/HYPOTHESIS Islet amyloid polypeptide (IAPP) is a beta cell hormone secreted together with insulin upon glucose stimulation. IAPP participates in normal glucose regulation, but IAPP is also known for its ability to misfold and form islet amyloid. Amyloid fibrils form through smaller cell toxic intermediates and deposited amyloid disrupts normal islet architecture. Even though IAPP and amylo...

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ژورنال

عنوان ژورنال: Journal of Endocrinology and Diabetes

سال: 2016

ISSN: 2374-6890

DOI: 10.15226/2374-6890/3/6/00156