Plasma Cell Labeling Index in the Evaluation of Smoldering (Asymptomatic) Multiple Myeloma
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چکیده
منابع مشابه
Smoldering Multiple Myeloma
Smoldering multiple myeloma (SMM) is an asymptomatic precursor stage of multiple myeloma (MM) characterized by clonal bone marrow plasma cells (BMPC) ≥ 10% and/or M protein level ≥ 30 g/L in the absence of end organ damage. It represents an intermediate stage between monoclonal gammopathy of undetermined significance (MGUS) and symptomatic MM. The risk of progression to symptomatic MM is not un...
متن کامل[Smoldering multiple myeloma].
Smoldering multiple myeloma (SMM) is an asymptomatic plasma cell neoplasia, characterized by monoclonal plasma cell proliferation in the absence of end-organ damage, but with a high risk of progression to multiple myeloma. It has therefore to be distinguished from monoclonal gammapathy of undetermined significance (MGUS), which has a much lower risk of progression, but also from multiple myelom...
متن کاملV. Smoldering multiple myeloma.
Smoldering multiple myeloma (SMM) is an asymptomatic plasma cell disorder defined in 1980 by Kyle and Greipp on the basis of a series of six patients who met the criteria for multiple myeloma (MM) but whose disease did not have an aggressive course [1]. At the end of 2014, the International Myeloma Working Group (IMWG) updated the definition, and SMM is now defined as a plasma cell disorder cha...
متن کاملHow I treat smoldering multiple myeloma.
Smoldering myeloma is a heterogeneous clinical entity where a subset of patients has an indolent course of disease that mimics monoclonal gammopathy of undermined significance, whereas others have a more aggressive course that has been described as "early myeloma." It is defined as either serum M-protein ≥ 3 g/L or ≥ 10% monoclonal plasma cells in the bone marrow. There are currently no molecul...
متن کاملAn Unusual Presentation of Plasma Cell Leukemia with Undiagnosed Multiple Myeloma
A 54 year old man with history of cardiomyopathy and chronic fibrillation first presented with bloody diarrhea. Then during the assessment of his abnormal lab. data revealed cast nephropathy in renal biopsy, gamma peak in protein electrophoresis and fine lytic lesions in skull graphy. His bone marrow asp...
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ژورنال
عنوان ژورنال: Mayo Clinic Proceedings
سال: 2010
ISSN: 0025-6196
DOI: 10.4065/mcp.2009.0653