Plasma Homocyst(e)ine Concentration, But NotMTHFRGenotype, Is Associated With Variation in Carotid Plaque Area
نویسندگان
چکیده
منابع مشابه
Plasma homocyst(e)ine concentration, but not MTHFR genotype, is associated with variation in carotid plaque area.
BACKGROUND AND PURPOSE Elevated plasma homocyst(e)ine [H(e)] concentration is associated with premature atherosclerosis. A common cause of elevated plasma H(e) concentration is a thermolabile mutation (677T) in the gene encoding methylenetetrahydrofolate reductase (MTHFR). We sought to determine whether plasma H(e) concentration or MTHFR genotype would be more strongly associated with carotid p...
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There are several problems with the report of Li et al. They studied sex differences, not gender differences. They referred to carotid intima-media thickness (IMT) as atherosclerosis; it is not, and plaque burden is a much stronger predictor of cardiovascular risk than IMT. They referred to levels of homocysteine (Hcy), but almost certainly what they measured was total homocysteine (tHcy), whic...
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ژورنال
عنوان ژورنال: Stroke
سال: 1999
ISSN: 0039-2499,1524-4628
DOI: 10.1161/01.str.30.5.969