Plasmid segregation without partition
نویسندگان
چکیده
منابع مشابه
Plasmid segregation and accumulation
The segregation of plasmids in a bacterial population is investigated. Hereby, a dynamical model is formulated in terms of a size-structured population using a hyperbolic partial differential equation incorporating non-local terms (the fragmentation equation). For a large class of parameter functions this PDE can be re-written as an infinite system of ordinary differential equations for the mom...
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Bacterial plasmids encode partitioning (par) loci that ensure ordered plasmid segregation prior to cell division. par loci come in two types: those that encode actin-like ATPases and those that encode deviant Walker-type ATPases. ParM, the actin-like ATPase of plasmid R1, forms dynamic filaments that segregate plasmids paired at mid-cell to daughter cells. Like microtubules, ParM filaments exhi...
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DNA segregation or partition is an essential process that ensures stable genome transmission. In prokaryotes, partition is best understood for plasmids, which serve as tractable model systems to study the mechanistic underpinnings of DNA segregation at a detailed atomic level owing to their simplicity. Specifically, plasmid partition requires only three elements: a centromere-like DNA site and ...
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Remarkably little is known about how bacterial chromosomes and their plasmids are partitioned to daughter cells prior to cell division, despite extensive experimentation and bioinformatic analysis. An in vitro study described in the current issue of The EMBO Journal recapitulates many features of plasmid partition in vivo and provides insight into how protein patterning on the nucleoid, determi...
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Unlike the mitotic segregation of eukaryotic sister chromatids, DNA partitioning in bacteria is still not well understood. Bacterial high–copy-number plasmids can be stably maintained by random distribution of their copies during cell division. In contrast, the faithful transmission of low–copy-number plasmids and many chromosomes depends on an active process mediated by conserved, tripartite s...
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ژورنال
عنوان ژورنال: Mobile Genetic Elements
سال: 2011
ISSN: 2159-256X
DOI: 10.4161/mge.1.3.18229