Platelet Aggregation Inhibitory Agents: From RGD to Peptide Mimetics.
نویسندگان
چکیده
منابع مشابه
Design and Synthesis of RGD Mimetics as Potent Inhibitors of Platelet Aggregation
Vascular diseases, such as heart attacks and strokes, are known to be caused by the aggregation of platelets which form clots within blood vessels. These diseases can be prevented through the use of drugs that inhibit platelet aggregation by blocking a key platelet receptor, GPIIb/IIIa. The recognition of the arginine-glycine-aspartic acid (RGD) amino acid sequence by this receptor has been exp...
متن کاملA Novel Direct Factor Xa Inhibitory Peptide with Anti-Platelet Aggregation Activity from Agkistrodon acutus Venom Hydrolysates
Snake venom is a natural substance that contains numerous bioactive proteins and peptides, nearly all of which have been identified over the last several decades. In this study, we subjected snake venom to enzymatic hydrolysis to identify previously unreported bioactive peptides. The novel peptide ACH-11 with the sequence LTFPRIVFVLG was identified with both FXa inhibition and anti-platelet agg...
متن کاملInhibitory Effect of Propolis on Platelet Aggregation In Vitro
Platelet hyperactivity plays an important role in arterial thrombosis and atherosclerosis. The present study was aimed to investigate the effects of different extracts of propolis and components of flavonoids on platelet aggregation. Platelet-rich plasma was prepared and incubated in vitro with different concentrations of the tested extracts and components of flavonoids. Platelets aggregation w...
متن کاملStructure-activity relationships of RGD mimetics as fibrinogen-receptor antagonists.
The activities of a series of RGD mimetics, which contained a variety of cationic structures, for the inhibition of platelet aggregation and fibrinogen-receptor binding were measured. The stability of the coulombic ion-pairing complex of the model compounds with the acetate anion as a model for the receptor was calculated in terms of the ionic interaction energy. The results suggest that stabil...
متن کاملPlatelet aggregation studies: autologous platelet-poor plasma inhibits platelet aggregation when added to platelet-rich plasma to normalize platelet count.
Adjusting platelet count (PC) in platelet-rich plasma (PRP) using platelet-poor plasma (PPP) is recommended for platelet aggregation (PA) studies, but it could also affect PA independently of the decrease in PC. Analysis of aggregation tracings from healthy controls showed that PC correlated with PA in 47 diluted-PRPs, but not in 104 undiluted-PRPs. Dilution of 9 PRPs with PPP progressively dec...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Synthetic Organic Chemistry, Japan
سال: 1994
ISSN: 0037-9980,1883-6526
DOI: 10.5059/yukigoseikyokaishi.52.413