Platelet functional responses and signalling: the molecular relationship. Part 2: receptors.

Small, non-nuclear cells, platelets, are primarily designed to form aggregates when blood vessels damaged, stopping bleeding. To perform this function, platelets can implement several functional responses induced by various agonists and coordinated a complex network of intracellular signaling triggered dozen different receptors. This review, the second in series, describes known pathways platelet receptors response canonical rare agonists. Particular focus will be on interaction points “synergy” activation intermediate or “secondary” mediators that transmit signal manifestations.