Pluripotency and Cellular Reprogramming: Facts, Hypotheses, Unresolved Issues
نویسندگان
چکیده
منابع مشابه
Pluripotency and Cellular Reprogramming: Facts, Hypotheses, Unresolved Issues
Direct reprogramming of somatic cells to induced pluripotent stem cells by ectopic expression of defined transcription factors has raised fundamental questions regarding the epigenetic stability of the differentiated cell state. In addition, evidence has accumulated that distinct states of pluripotency can interconvert through the modulation of both cell-intrinsic and exogenous factors. To full...
متن کاملFocus on induced pluripotency and cellular reprogramming.
T he concept of ‘induced pluripotency’ stems from research showing that embryonic and differentiated cells are genetically identical and that a handful of transcription factors are sufficient to revert the fate of any given cell. The Nobel Prize-winning discovery of transcription factor-based ‘reprogramming’ inspired many laboratories to define conditions for the derivation, expansion, and diff...
متن کاملChromatin Connections to Pluripotency and Cellular Reprogramming
The pluripotent state of embryonic stem cells (ESCs) provides a unique perspective on regulatory programs that govern self-renewal and differentiation and somatic cell reprogramming. Here, we review the highly connected protein and transcriptional networks that maintain pluripotency and how they are intertwined with factors that affect chromatin structure and function. The complex interrelation...
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Citicoline is the generic name of the pharmaceutical substance that chemically is cytidine-5'-diphosphocholine (CDP-choline), which is identical to the natural intracellular precursor of phospholipid phosphatidylcholine. Following injection or ingestion, citicoline is believed to undergo quick hydrolysis and dephosphorylation to yield cytidine and choline, which then enter the brain separately ...
متن کاملPoly(ADP-Ribose) Polymerase 1: Cellular Pluripotency, Reprogramming, and Tumorogenesis
Poly(ADP-ribos)ylation (PARylation) is the catalytic function of the Poly(ADP-ribose) polymerases (Parps) family for post-translational modification in cellular process. Being a major member of Parps, Parp1 is a crucial nuclear factor with biological significance in modulating DNA repair, DNA replication, transcription, DNA methylation and chromatin remodeling through PARylation of downstream p...
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ژورنال
عنوان ژورنال: Cell
سال: 2010
ISSN: 0092-8674
DOI: 10.1016/j.cell.2010.10.008