<p>Myelin basic protein charge isomers change macrophage polarization</p>
نویسندگان
چکیده
منابع مشابه
Charge Isomers of Myelin Basic Protein: Structure and Interactions with Membranes, Nucleotide Analogues, and Calmodulin
As an essential structural protein required for tight compaction of the central nervous system myelin sheath, myelin basic protein (MBP) is one of the candidate autoantigens of the human inflammatory demyelinating disease multiple sclerosis, which is characterized by the active degradation of the myelin sheath. In this work, recombinant murine analogues of the natural C1 and C8 charge component...
متن کاملDetermination of the sites of posttranslational modifications in the charge isomers of bovine myelin basic protein by capillary electrophoresis-mass spectroscopy.
The posttranslational modifications in each of the 18.5 kDa bovine myelin basic protein charge isomers C-1 to C-6 have been determined by the use of capillary electrophoresis-mass spectroscopy. The pattern of modifications is viewed as being unique to each charge isomer and is thought to reflect a specific placement and function for each isomer in the myelin membrane. Several of the sites of po...
متن کاملKinetics of carboxylmethylation of the charge isoforms of myelin basic protein by protein methyltransferase II.
The charge isoforms (C1-C5) of bovine myelin basic protein (MBP) were used as substrates for the rat brain enzyme protein carboxylmethyltransferase (PM II). The objective of these experiments was to ascertain whether the kinetic behavior of the MBP isoforms reflected differences in the structures of this molecular family. Initial velocity plots as a function of the MBP-isoform concentration sho...
متن کاملBasic Infobase Change
Generalisations of theory change involving arbitrary sets of wffs instead of belief sets have become known as base change. In one view, a base should be thought of as providing more structure to its generated belief set, and can be used to determine the theory change operation associated with a base change operation. In this paper we extend a proposal along these lines by Meyer et al. [12]. We ...
متن کاملSerum and Saliva Myelin Basic Protein as Multiple Sclerosis Biomarker
Objective: Multiple sclerosis (MS) is presented with motor and sensory function loss. It is caused by demyelination and following axonal lesion. As myelin basic protein (MBP) is one of the key elements of the myelin cover, we examined the level of MBP in serum, stimulated, and unstimulated saliva as a suitable biomarker for detecting MS. Methods: A case-control study was performed in 29 health...
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ژورنال
عنوان ژورنال: Journal of Inflammation Research
سال: 2019
ISSN: 1178-7031
DOI: 10.2147/jir.s189570