Polymorphisms and Methylation of the Reduced Folate Carrier in Osteosarcoma
نویسندگان
چکیده
منابع مشابه
Sequence alterations in the reduced folate carrier are observed in osteosarcoma tumor samples.
High-dose methotrexate is a standard component of therapy for high-grade osteosarcoma. Its effectiveness may be limited by intrinsic and acquired resistance. Decreased reduced folate carrier (RFC) expression has been shown in approximately half of osteosarcomas at diagnosis. Mutations and polymorphisms in the RFC gene have been reported in various cell lines. The purpose of this study was to in...
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Folate metabolism supports the synthesis of nucleotides as well as the transfer of methyl groups. Polymorphisms in folate-metabolizing enzymes have been shown to affect risk of colorectal neoplasia and other malignancies. Using data from a population-based incident case-control study (1,600 cases and 1,962 controls), we investigated associations between genetic variants in the reduced folate ca...
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ژورنال
عنوان ژورنال: Clinical Orthopaedics and Related Research
سال: 2008
ISSN: 0009-921X,1528-1132
DOI: 10.1007/s11999-008-0323-3