POS-018 PHASE CONTRAST MAGNETIC RESONANCE IMAGING TO ASSESS RENAL PERFUSION IN PATIENTS WITH C3 GLOMERULOPATHY OR IMMUNE-COMPLEX MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS

IntroductionPhase-contrast magnetic resonance imaging (PC-MRI) is a non-invasive method used to compute blood flow velocity and volume, alongside several derivative hemodynamic parameters. Renal (RBF) assessment important for the diagnosis monitoring of range renal diseases, in which it decreases since earliest stages. The aim this study was elucidate PC-MRI potential as biomarker perfusion function cohort patients with C3 Glomerulopathy (C3G) or Immune-Complex Membranoproliferative Glomerulonephritis (IC-MPGN).MethodsMRI clinical data were collected from 7 C3G IC-MPGN, context non-contrast enhanced (NCE) MRI subproject pharmacological trial (NCT03723512). All underwent NCE-MRI at two time points (before after 1 year treatment ACH-0144471) addition evaluation, laboratory testing, GFR measurement by Iohexol clearance, baseline kidney biopsy. Cardiac-gated 2D PC velocity-sensitive sequence acquired breath-hold on each artery investigate perfusion. Total RBF computed sum left right flow. plasma (RPF) * (1 – hematocrit); vascular resistance (RVR) mean arterial pressure divided RPF; filtration fraction (FF) RPF. Peritubular interstitial volume quantified biopsy specimens stained PAS point counting. correlation between parameters histological findings investigated Spearman’s correlation.ResultsAlbumin creatinine ratio (A/C) all available negatively associated RBF, RPF, FF (rho=-0.86, p<0.001; rho=-0.84, rho=-0.6, p=0.043, respectively), while positively correlated RVR (rho=0.88, p<0.001), shown Figure 1A. Measured (mGFR) (rho=0.87, rho=0.68, p=0.019; rho=0.85, p<0.001, (rho=-0.89, 1B. Moreover, peritubular (rho=-0.81, p=0.022) showed trend towards negative association RPF (rho=-0.52, p=0.2) positive (rho=0.65, p=0.083).View Large Image ViewerDownload Hi-res image Download (PPT)ConclusionsThe strong significant found PC-MRI-based findings, despite rather limited number patients, highlights assess stage damage IC-MPGN. Future larger studies are needed confirm current findings.No conflict interest (IC-MPGN). Phase-contrast MethodsMRI correlation. ResultsAlbumin p=0.083). Albumin ConclusionsThe findings.