POS0738 BLUNTED CEREBRAL OXYGENATION DURING EXERCISE IN NON-NEUROPSYCHIATRIC SYSTEMIC LUPUS ERYTHEMATOSUS

Background: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease affecting multiple organs, including the central nervous system. Subclinical brain lesions have been reported in SLE patients, even without overt neuropsychiatric manifestations (non-NPSLE). Studies using PET/MRI, examining structural or functional abnormalities SLE, previously performed, either at rest during mental task (1–3). Exercise can be used to identify early alterations oxygenation that might not detectable resting conditions (4). Objectives: Our study aimed examine possible differences cerebral handgrip exercise test between patients and age-matched controls. Methods: Fifty-two participants (26 non-NPSLE 26 controls), following evaluation of strength, underwent protocol involving seated (baseline), 3-min (at 30% maximal strength), recovery. Continuous-near-infrared-spectroscopy (NIRS) was monitor changes cerebral-oxygenated hemoglobin (O2Hb), de-oxygenated (HHb) total-hemoglobin (tHb). Beat-by-beat blood pressure (Finapres) continuously monitored. Results: There were no two groups age, body mass index, pressure, smoking status. Median duration 7.5 (3.0 – 16.0) years. During exercise, -O2Hb increased both groups; however, exhibited significantly lower increase O2Hb vs. controls (average response:1.20±0.89 2.33±1.61μM, respectively, p<0.005) tHb responses (p<0.05), with HHb. Conclusion: data show, for first time, exhibit blunted cerebral-O2Hb submaximal stimulus compared Examining simple may assist identifying function. References: [1]Mak A, Ren T, Fu EH yun, Cheak AA cia, Ho RCM. A Prospective Functional MRI Study Executive Function Patients Lupus Erythematosus Without Neuropsychiatric Symptoms. Semin Arthritis Rheum. 2012;41(6):849–58. [2]Kozora E, Brown MS, Filley CM, Zhang L, Miller DE, West SG, et al. Memory impairment associated neurometabolic hippocampus non-neuropsychiatric systemic erythematosus. Lupus. 2011;20(6):598–606. [3]Mackay M, Vo Tang CC, Small Anderson EW, Ploran EJ, Metabolic microstructural correlate cognitive impairment. JCI Insight. 2019;4(1). [4]Triantafyllou GA, Dipla K, Triantafyllou Gkaliagkousi Douma S. Measurement Changes Cerebral Oxygenation Blood Flow Rest Normotensive Hypertensive Individuals. Vol. 22, Current Hypertension Reports. Springer; 2020. Disclosure Interests: None declared