POS0846 SEXUAL FUNCTION IS IMPAIRED IN WOMEN WITH SYSTEMIC SCLEROSIS COMPARED TO HEALTHY CONTROLS

Background: Systemic sclerosis (SSc) is a multisystem, connective tissue disorder characterized by fibrosis of the skin and internal organ involvement, which can influence all aspects life, including sexual life. Objectives: This study aimed to compare function in patients with SSc age-/sex-matched healthy controls (HC) determine potential impact clinical features on function. Methods: In total, 90 women (mean age: 49.1, disease duration: 6.1 years, lcSSc/dcSSc: 62/28, mRSS: 9.3, ESSG activity index: 2.1), who fulfilled ACR/EULAR 2013 criteria, 49.1) without rheumatic diseases filled 12 well-established validated questionnaires assessing (FSFI, BISF-W, SFQ-28, SQoL-F), pelvic floor (PISQ-12, PFIQ-7), fatigue (FIS, Fatigue Impact Scale), physical (HAP, Human Activity Profile), disability (HAQ, Health Assessment Questionnaire), depression (BDI-II, Beck’s Depression Inventory-II) quality life (SF-36, Medical outcomes Short Form 36 – PCS, Physical Component Summary; MCS, Mental Summary). A routine laboratory testing was performed. Data are presented as median (IQR). Results: Patients reported significantly greater prevalence severity dysfunction SFQ28 subscales well total scores), worse (SQoL-F) PFIQ-7) compared HC (table 1). The according FSFI cut-off score 77%. Worse scores were associated longer duration [BISF-W-total (r=-0.243,p=0.026), FSFI-lubrication (r=-0.229,p=0.035)], higher [ESSG BISF-W-total (r=-0.291,p=0.010), FSFI-arousal (r=-0.299,p=0.007)], increased inflammation [CRP: BISF-W-receptivity/initiation (r=-0.301,p=0.007)], more pronounced [FIS-total: (r=-0.412,p<0.0001)], severe [BDI-II: FSFI-total (r=-0.506,p<0.0001), SQoL-F (r=-0.369, p<0.0001)], functional [HAQ: (r=-0.394,p<0.0001)], reduced [HAP: (r=0.535,p<0.0001)], decreased overall [SF-36 PCS: (r=0.428,p<0.0001), SF-36 MCS: (r=0.472, p<0.0001)]. Conclusion: Women impaired controls. disease-related features. Table 1. Sexual Questionnaire: range (meaning ) (n=90 p-value FSFI: Female 2 (worst) - (best) 19.4 (3.9-26.8) 30.1 (23.1-32.9) p<0.0001 BISF-W : Brief Index Function for Women: -16 75 14.3 (2.1-35.1) 38.2 (19.3-46.2) SQoL-F: Quality Life Questionnaire-Female: 0 100 61.1 (34.4-81.1) 91.1 (70.0-96.7) PISQ-12: Pelvic Organ Prolapse/Urinary Incontinence Questionnaire short form: 48 13.0 (9.0-17.0) 7.0 (5.0-12.0) PFIQ-7: Floor Distress Inventory 300 9.5 (0.0-48.8) 0.0 (0.0-8.3) SFQ-28: Functioning Questionnaire-28 desire: 5 31 17.0 (12.0-20.0) 21.0 (17.0-23.0) SFQ-28 arousal sensation: 4 20 10.0 (8.0-13.0) 12.0 (9.0-15.0) p=0.0031 lubrication: 10 5.0 (4.0-7.0) 8.0 (5.2-9.0) cognitive: (4.0-6.0) (5.0-8.0) orgasm: 1 15 (6.5-12.0) (10.0-13.0) pain: (9.5-15.0) 15.0 (13.0-15.0) enjoyment: 6 30 19.0 (12.5-24.0) 24.0 (20.0-25.8) partner: 9.0 (8.0-10.0) 10. (9.0-10.0) p=0.0182 Acknowledgements: Supported MHCR 023728, GA UK 1578119, SVV 260373. Disclosure Interests: None declared