Positional Cloning of Skeletal Mouse Mutation, Tail Short(Ts).
نویسندگان
چکیده
منابع مشابه
Positional Cloning of the Mouse Circadian ClockGene
We used positional cloning to identify the circadian Clock gene in mice. Clock is a large transcription unit with 24 exons spanning approximately 100,000 bp of DNA from which transcript classes of 7.5 and approximately 10 kb arise. Clock encodes a novel member of the bHLH-PAS family of transcription factors. In the Clock mutant allele, an A-->T nucleotide transversion in a splice donor site cau...
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Crinkly-tail, cy, is a new recessive mutant with imperfect penetrance, in chromosome 4 of the mouse. The only abnormality is in the shape of the vertebrae for one, more rarely two, lengths of the region C9 to C14. This is expressed briefly in the 11-day-old embryo as a duplicated tail gut. None of the mechanisms operating in most of the 20 known tail mutants in the mouse operates in crinkly-tai...
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Genetic mapping and positional cloning of genetically complex traits in the laboratory rat (Rattus norvegicus) has recently led to the identification of various susceptibility genes in different rat models. Rat genetics has benefited from revolutionary advances in molecular biology, genetics, genomics and informatics and provide an unparalleled resource for molecular genetic investigation of ma...
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Genetic linkage maps of molecular markers have facilitated the identification of quantitative trait loci (QTL) for economically important traits in a variety of cultured fish species (Tao and Boulding 2003, Cnaani et al. 2004, Reid et al. 2005). In rainbow trout, several QTLs have been identified for disease resistance (Palti et al. 1999, Ozaki et al. 2001), environmental stress tolerance (Danz...
متن کامل"Bent-Tail," A Dominant, Sex-Linked Mutation in the Mouse.
Although sex-linkage in animals is no longer an unusual phenomenon, its apparent rarity in rodents is noteworthy, especially in the intensively studied house mouse and rat. Hauschka, et al.,1 have presented evidence for a sex-linked lethal altering the sex ratio in the house mouse; Falconer2 recently reported a second sex-linked mutation in the house mouse. A third sex-linked mutation, Bent-tai...
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ژورنال
عنوان ژورنال: Proceedings of The Japanese Society of Animal Models for Human Diseases
سال: 1996
ISSN: 0918-8991,1884-4197
DOI: 10.1538/expanim1992.12.4