Positive Inotropic Effects of Imidazoline Derivatives Are Not Mediated via Imidazoline Binding Sites but α1-Adrenergic Receptors
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چکیده
منابع مشابه
The effects of imidazoline compounds on nociception in animal pain model
The discovery of imidazoline ligands has opened up a new field of study. The investigation of imidazoline actions independent of adrenoceptors started in the mid 1980s. Imidazoline receptors are classified in several subtypes, I1, I2 and I3 binding sites. Although imidazoline sites have been the subjects of research for several years, but there is still controversy about their actions especiall...
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The discovery of imidazoline ligands has opened up a new field of study. The investigation of imidazoline actions independent of adrenoceptors started in the mid 1980s. Imidazoline receptors are classified in several subtypes, I1, I2 and I3 binding sites. Although imidazoline sites have been the subjects of research for several years, but there is still controversy about their actions especiall...
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Over the past few years, a vast amount of research has shed light on the pharmacology of imidazoline binding sites (I-BS). To date, at least three classes of imidazoline binding sites have been characterised in accordance to their localisation, drug selectivity, proposed signalling pathways and functional roles. The existence of these sites raises the question as to whether an endogenous modula...
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Compounds with an imidazoline or guanidinium moiety elicit a variety of stimulatory and inhibitory cell responses in both central and peripheral tissues. Many of these effects are mediated by interaction with alpha-adrenergic receptors, but these molecules also selectively recognize other membrane-bound proteins with high affinity. We used a functionalized derivative of the imidazoline molecule...
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Clonidine, like many other imidazoline drugs, is usually thought of as a selective α2-adrenergic agonist and is approved for use as a centrally acting antihypertensive agent. In addition, clonidine is prescribed off-label to treat some cases of Tourette’s syndrome, and it may also have a role in the treatment of other psychiatric conditions, including obsessive–compulsive disorders, panic state...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 2000
ISSN: 0021-5198
DOI: 10.1254/jjp.84.1