Possible ameliorating effect of isoquercetin on diethylnitrosamine-induced hepatocellular carcinoma in albino mice

The majority of cases liver cancer are discovered late in the disease’s progression, making it third leading cause death globally. Chemotherapy is major treatment choice for advanced stages hepatocellular carcinoma (HCC); however, drug resistance, adverse effects, and high cost problems effective treatment. Isoquercetin (IQ) a dietary flavonoid, which has an anti-proliferative effect against several cell lines. It also prophylactic early some models including HCC. purpose this study was to assess therapeutic anticarcinogenic IQ murine A single intraperitoneal (ip) dose 100 mg/kg diethylnitrosamine (DEN), followed by 18 weekly ip doses 0.5 carbon-tetrachloride (CCl4) used induce After induction HCC, (10 20 bw) given orally from week 21 24. most likely ameliorated structure function livers with experimentally induced HCC improving survival rate, significantly reducing tumor marker alpha-fetoprotein (AFP), number hepatic nodules downstaging This accompanied increase endogenous antioxidant capacity suppressor protein ‘p53’, as well lower levels lipid peroxidation malondialdehyde (MDA), proliferation proliferating nuclear antigen (PCNA) angiogenesis vascular endothelial growth factor (VEGF) tissues. suppresses proliferation, oxidative stress, activating p53 inhibiting angiogenesis.