Postulated release profile of recombinant human bone morphogenetic protein-2 (rhBMP-2) from demineralized dentin matrix
نویسندگان
چکیده
منابع مشابه
Demineralized dentin matrix combined with recombinant human bone morphogenetic protein-2 in rabbit calvarial defects
OBJECTIVES The aim of this study was to compare the osteogenic effects of demineralized dentin matrix (DDM) combined with recombinant human bone morphogenetic protein-2 (rhBMP-2) in rabbit calvarial defects with DDM and anorganic bovine bone (ABB) combined with rhBMP-2. MATERIALS AND METHODS Four round defects with 8-mm diameters were created in each rabbit calvaria. Each defect was treated w...
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We aimed to evaluate the efficacy of demineralized dentin matrix (DDM) fixed with recombinant human bone morphogenetic protein-2 (rhBMP-2) through an experimental and a clinical study. Unilateral upper second and third premolars of eight beagles were extracted. A mucoperiosteal flap was elevated around the extraction socket, and a bone defect was made using a surgical drill. Each DDM was fixed ...
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In recent years, recombinant human bone morphogenetic protein-2 (rhBMP-2) has been introduced as a therapeutic option in the treatment of several congenital and acquired craniofacial defects. Although there have been promising clinical results, the international literature still lacks complete guidelines, including limits and indications for the use of rhBMP-2. The possible indications for rhBM...
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Osteolysis may occur following lumbar interbody fusion procedures in which recombinant human bone morphogenetic protein-2, more commonly known as rhBMP-2, is used. The actual incidence of this process is unknown. Osteolysis results from an osteoclastic, rather than an osteoblastic response to rhBMP-2 and its carrier on trabecular vertebral bone, early in the sequence of bone graft healing. This...
متن کاملBone Engineering Using Human Demineralized Dentin Matrix and Recombinant Human BMP-2
We first confirmed the osteoinductive property of human demineralized dentin matrix (DDM) histologically. Human DDM was prepared from vital, extracted teeth and implanted into the subcutaneous tissue in nude mice. The shape of the DDM was a particle type and its size varied from 0.4 to 0.8 mm. The hard tissue induction by 70 mg of the DDM was estimated at 4 weeks after implantation. The DDM ind...
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ژورنال
عنوان ژورنال: Journal of the Korean Association of Oral and Maxillofacial Surgeons
سال: 2019
ISSN: 2234-7550,2234-5930
DOI: 10.5125/jkaoms.2019.45.3.123