Power and major gene-gene identification of dummy multifactor dimensionality reduction algorithm
نویسندگان
چکیده
منابع مشابه
Multifactor dimensionality reduction for detecting gene-gene and gene-environment interactions in pharmacogenomics studies.
In the quest for discovering disease susceptibility genes, the reality of gene-gene and gene-environment interactions creates difficult challenges for many current statistical approaches. In an attempt to overcome limitations with current disease gene detection methods, the multifactor dimensionality reduction (MDR) approach was previously developed. In brief, MDR is a method that reduces the d...
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MOTIVATION Polymorphisms in human genes are being described in remarkable numbers. Determining which polymorphisms and which environmental factors are associated with common, complex diseases has become a daunting task. This is partly because the effect of any single genetic variation will likely be dependent on other genetic variations (gene-gene interaction or epistasis) and environmental fac...
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MOTIVATION The identification and characterization of susceptibility genes that influence the risk of common and complex diseases remains a statistical and computational challenge in genetic association studies. This is partly because the effect of any single genetic variant for a common and complex disease may be dependent on other genetic variants (gene-gene interaction) and environmental fac...
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ژورنال
عنوان ژورنال: Journal of the Korean Data and Information Science Society
سال: 2013
ISSN: 1598-9402
DOI: 10.7465/jkdi.2013.24.2.277