PP-147 Construction of a chimeric GB virus B with hepatitis C virus NS2-NS4A
نویسندگان
چکیده
منابع مشابه
Virus-specific cofactor requirement and chimeric hepatitis C virus/GB virus B nonstructural protein 3.
GB virus B (GBV-B) is closely related to hepatitis C virus (HCV) and causes acute hepatitis in tamarins (Saguinus species), making it an attractive surrogate virus for in vivo testing of anti-HCV inhibitors in a small monkey model. It has been reported that the nonstructural protein 3 (NS3) serine protease of GBV-B shares similar substrate specificity with its counterpart in HCV. Authentic prot...
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Background and Aims: Many studies have provided evidence for the role of hepatitis B and C viruses in the development of liver cancer. Although the routine treatment is available for both conditions, no definite guideline is available to treat patients dually infected with HBV and HCV. This study was performed to determine the frequency of HBV/HCV-coinfection in Mashhad, North-East of Iran. Mat...
متن کاملNS2 proteins of GB virus B and hepatitis C virus share common protease activities and membrane topologies.
UNLABELLED GB virus B (GBV-B), which is hepatotropic in experimentally infected small New World primates, is a member of the Hepacivirus genus but phylogenetically relatively distant from hepatitis C virus (HCV). To gain insights into the role and specificity of hepaciviral nonstructural protein 2 (NS2), which is required for HCV polyprotein processing and particle morphogenesis, we investigate...
متن کاملGB virus-C (hepatitis G virus) nostalgia.
The newly discovered human flavivirus identified as GB virus-C [1] and hepatitis G virus (HGV) [2], presents intriguing challenges in virology, epidemiology, and blood banking. Its clinical relevance for hepatology, however, appears to have been short-lived. Murthy and colleagues in this issue of Kidney International [3] provide additional evidence that the virus is not associated with clinical...
متن کاملThe hepatitis C virus NS2/3 protease.
The hepatitis C virus NS2/3 protein is a highly hydrophobic protease responsible for the cleavage of the viral polypeptide between non-structural proteins NS2 and NS3. However, many aspects of the NS2/3 protease's role in the viral life cycle and mechanism of action remain unknown. Based on the recently elucidated crystal structure of NS2, NS2/3 has been proposed to function as a cysteine prote...
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ژورنال
عنوان ژورنال: International Journal of Infectious Diseases
سال: 2010
ISSN: 1201-9712
DOI: 10.1016/s1201-9712(10)60215-9