<p>Patient-reported outcomes of dual bronchodilator fixed-dose combination versus bronchodilator monotherapy in individuals with COPD</p>

Combination bronchodilator therapy in COPD.

Dual bronchodilator therapy: A review

Inhaled bronchodilators with or without inhaled steroids (IGCs) are the mainstay of pharmacological treatment for stable obstructive airway diseases, including beta2agonists and muscarinic antagonists. Long-acting muscarinic antagonist bronchodilators (LAMA) and long-acting β2-agonists (LABA) are the treatment of choice for moderate to severe chronic obstructive pulmonary disease (COPD). Also, ...

Cost-effectiveness and budget impact of the fixed-dose dual bronchodilator combination tiotropium–olodaterol for patients with COPD in the Netherlands

PURPOSE The fixed-dose dual bronchodilator combination (FDC) of tiotropium and olodaterol showed increased effectiveness regarding lung function and health-related quality of life in patients with chronic obstructive pulmonary disease (COPD) compared with the use of its mono-components. Yet, while effectiveness and safety have been shown, the health economic implication of this treatment is sti...

Bronchodilator delivery with metered-dose inhalers in mechanically-ventilated patients.

Metered-dose inhalers (MDIs) provide several advantages over nebulizers, including ease of administration, decreased cost, reliability of dosing, and freedom from contamination. However, this method of aerosol delivery has been considered ineffective in mechanically-ventilated patients because most of the aerosol deposits in the endotracheal tube and ventilator circuit. A smaller amount of aero...

Bronchodilator Responsiveness and Reported Respiratory Symptoms in an Adult Population

BACKGROUND The relationship between patient-reported symptoms and objective measures of lung function is poorly understood. AIM To determine the association between responsiveness to bronchodilator and respiratory symptoms in random population samples. METHODS 4669 people aged 40 years and older from 8 sites in Canada completed interviewer-administered respiratory questionnaires and perform...