Pre-clustered TCR complexes

CNplot: visualizing pre-clustered networks.

SUMMARY CNplot is a simple technique for the visualization of global connectivity within pre-clustered network data. CNplot is easy to implement and in most cases produces informative and satisfactory summary of the data. AVAILABILITY A Java implementation is available that allows users to modify graphics parameters and produces a LaTeX output. This software is free and is available at http:/...

Clustered Pre-convolved Radiance Caching

We present a scalable method for rendering indirect illumination in diffuse and glossy scenes. Our method builds on pre-convolved radiance caching (RC), which enables reusing the incident radiance computed at a surface point for its neighborhood. Our contributions include efficient and robust generation of these RCs based on a pre-filtered voxel representation that stores scene-geometry and sur...

TCR Transmembrane Tyrosines Are Required for Pre-TCR Function

TCR Microclusters pre-exist and contain molecules necessary for TCR signal transduction.

TCR-dependent signaling events have been observed to occur in TCR microclusters. We found that some TCR microclusters are present in unstimulated murine T cells, indicating that the mechanisms leading to microcluster formation do not require ligand binding. These pre-existing microclusters increase in absolute number following engagement by low-potency ligands. This increase is accompanied by a...

TCRA gene rearrangement in immature thymocytes in absence of CD3, pre-TCR, and TCR signaling.

During thymocyte differentiation, TCRA genes are massively rearranged only after productively rearranged TCRB genes are expressed in association with pTalpha and CD3 complex molecules within a pre-TCR. Signaling from the pre-TCR via the CD3 complex is thought to be required to promote TCRA gene accessibility and recombination. However, alphabeta(+) thymocytes do develop in pTalpha-deficient mic...