Predicting Optimal Resolving Power for Ambient Pressure Ion Mobility Spectrometry

Development of atmospheric pressure ionization ion mobility spectrometry and ion mobility spectrometry mass spectrometry

Overtone mobility spectrometry: part 2. Theoretical considerations of resolving power.

The transport of ions through multiple drift regions is modeled to develop an equation that is useful for an understanding of the resolving power of an overtone mobility spectrometry (OMS) technique. It is found that resolving power is influenced by a number of experimental variables, including those that define ion mobility spectrometry (IMS) resolving power: drift field (E), drift region leng...

Tandem differential mobility spectrometry with ion dissociation in air at ambient pressure and temperature.

Proton-bound dimers were dissociated to protonated monomers in air at ambient pressure and temperature using electric fields of ultrahigh Field Asymmetric Ion Mobility Spectrometry (ultraFAIMS) with the onset of dissociation for ethyl acetate as 96 Td and for dimethyl methyl phosphonate as 170 Td. Ions then were measured by differential mobility spectrometry (DMS). Fragment ions were formed wit...

Rapid screening of aqueous chemical warfare agent degradation products: ambient pressure ion mobility mass spectrometry.

The use of electrospray ionization ambient pressure ion mobility spectrometry with an orthogonal reflector time-of-flight mass spectrometer to analyze chemical warfare (CW) degradation products from aqueous environmental samples has been demonstrated. Certified reference materials of analytical standards for the detection of Schedule 1, 2, or 3 toxic chemicals or their precursors as defined by ...

Rapid separation of phenylthiohydantoin amino acids: ambient pressure ion-mobility mass spectrometry (IMMS).

An electrospray ionization (ESI) ambient pressure ion-mobility spectrometer (APIMS) interfaced to an orthogonal reflector time-of-flight mass spectrometer (TOFMS) was evaluated for the first time as a detector for the identification of phenylthiohydantoin (PTH)-derivatized amino acids, the final products in the Edman sequencing process of peptides and proteins. The drift and flight times of the...