Prediction of Protein-Protein Interaction Sites Using Electrostatic Desolvation Profiles
نویسندگان
چکیده
منابع مشابه
Prediction of protein-protein interaction sites using electrostatic desolvation profiles.
Protein-protein complex formation involves removal of water from the interface region. Surface regions with a small free energy penalty for water removal or desolvation may correspond to preferred interaction sites. A method to calculate the electrostatic free energy of placing a neutral low-dielectric probe at various protein surface positions has been designed and applied to characterize puta...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2010
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2009.12.4332