Preparation and characterization of etoricoxib-β-cyclodextrin complexes prepared by the kneading method

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Preparation and characterization of etoricoxib-beta-cyclodextrin complexes prepared by the kneading method.

The binary system of etoricoxib with beta-cyklodextrin (beta-CD) was prepared by the kneading method. Drug-cyclodextrin interactions in solution were investigated by the phase solubility analysis. Differential scanning calorimetry, infrared spectroscopy, powder X-ray diffractometry and microscopic study were used to characterize the solid state of all binary systems, whereas their dissolution p...

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Preparation, Characterization and Evaluation of Olmesartan Medoxomil-β Cyclodextrin Complexes

Olmesartan medoxomil is a poor water soluble drug. There are numerous approaches available and reported in literature to enhance the solubility of poor water soluble drugs among which cyclodextrin complexation is predominant. β-cyclodextrin was used since this possess a special ability to complex with drugs enabling them to increase solubility, reduce bitterness, enhance stability and decrease ...

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Preparationa and Characterization of domperidone Inclusion complexes with cyclodextrin: Influence of preparation method

Domperidone is a widely used antiemetic, poorly water soluble drug, erratically absorbed in stomach and possess several dissolution-related problems thus it has poor bioavailability. Solubility of a drug plays a very important role in dissolution and hence absorption of drug which ultimately affects its bioavailability. Hence, by considering the facts related to drug, attempts have been made to...

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Preparationa and Characterization of domperidone Inclusion complexes with cyclodextrin: Influence of preparation method

Domperidone is a widely used antiemetic, poorly water soluble drug, erratically absorbed in stomach and possess several dissolution-related problems thus it has poor bioavailability. Solubility of a drug plays a very important role in dissolution and hence absorption of drug which ultimately affects its bioavailability. Hence, by considering the facts related to drug, attempts have been made to...

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Comparative evaluation of ketoconazole-β-cyclodextrin systems prepared by coprecipitation and kneading.

Ketoconazole (KZ), an imidazole antifungal, was formulated into inclusion complexes via coprecipitation and kneading with β-cyclodextrin (β-CD) as a carrier in 1:1 and 1:2 drug to carrier ratios. The KZ-β-CD solid complexes were characterized by X-ray diffraction and differential scanning calorimetry (DSC). The diffraction pattern of the pure drug revealed the drug to be highly crystalline in n...

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ژورنال

عنوان ژورنال: Acta Pharmaceutica

سال: 2007

ISSN: 1846-9558,1330-0075

DOI: 10.2478/v10007-007-0028-2